Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-06-10
2000-02-01
Sisson, Bradley
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435194, 536 231, 536 232, 536 243, 536 2432, C12Q 168, C12N 912, C07H 2104, C07H 2102
Patent
active
060201282
ABSTRACT:
The nucleic acid sequence encoding the gene for the DNA polymerase I enzyme of Treponema pallidum, the organism causing syphilis. Nucleic acid molecules useful as probes for detecting Treponema pallidum are described. Isolated, recombinant, and synthetic DNA polymerase I enzyme of Treponema pallidum, and the amino acid sequence of the enzyme, are also described. Antibodies to DNA polymerase I from Treponema pallidum are further provided. The nucleic acid molecules are useful in methods for the detection and diagnosis of Treponema pallidum infection in a sample or subject.
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Steiner et al, Genbank Accession No. U57757, published Oct. 25, 1996.
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"Detection by Polymerase Chain Reaction of Treponema pallidum DNA in Cerebrospinal Fluid from Neurosyphilis Patients before and after Antibiotic Treatment", Noordhoek et al., Journal of Clinical Mcirobiology, Sep. 1991, vol. 29, No. 9, pp. 1976-1984.
"Simultaneous PCR Detection of Haemophilus decreyi, Treponema pallidum, and Herpes Simplex Virus Types 1 and 2 from Genital Ulcers", Orle et al., Journal of Clinical Microbiology, Jan. 1996, vol 34, No. 1, pp. 49-54.
"Use of polymerase chain reaction to detect DNA sequences specific to pathogenic treponemes in cerebrospinal fluid", Hay et al., FEMS Microbiology Letters 68, Mar. 15, 1990, vol. 68/3 pp. 233-238.
Sisson Bradley
Stole Einar
United States of Ameria
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