DNA plasmid vaccine for immunization of animals against BVDV

Details DNA plasmid vaccine for immunization of animals against BVDV DNA plasmid vaccine for immunization of animals against BVDV

1997-10-28

2000-05-09

Clark, Deborah J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 4352351, A61K 4800, C12N 700, C12N 1585

Patent

active

060604573

ABSTRACT:
The present invention relates to a DNA plasmid vaccine for immunization of animals against BVDV which comprises at least a mammalian expression vector having a DNA sequence encoding at least one BVDV immunogenic protein or fragment thereof which is selected from the group consisting of BVDV major glycoprotein gp53/E2, p20 (Npro), p14/C, gp48/E0, gp25/E1 and p80/NS3 proteins, the immunogenic protein is operably linked downstream from a suitable promoter for its expression, whereby inducing a BVDV-specific antibody responses.

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McDonnell et al. Molecular Medicine DNA vaccines. New England Journal of Medicine vol. 334 No. 1 pp. 42-45, Jan. 4, 1996.
Thompson, Larry. A shot in the arm for vaccine problems. The Washington Post section A p. 3, Jun. 7, 1993.
NIH Panel, Report and Recommendations of the Panel to assess the NIH investment in Research on gene therapy, Dec. 7, 1995.
Wiskerchen, et al. Pestivirus Gene Expression: the First Protein Product of the Bovine Viral Diarrhea Virus large open reading frame, p20, possesses proteolytic activity. J. of Virol. vol. 65, No. 8, pp. 4508-4514, Aug. 1991.

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