DNA participating in hydroxylation of macrolide compound

Details DNA participating in hydroxylation of macrolide compound DNA participating in hydroxylation of macrolide compound

2011-04-26

2011-04-26

Epps-Smith, Janet L. (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S320100, C536S023100, C536S023200, C536S023700

Reexamination Certificate

active

07932083

ABSTRACT:
The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, particularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (I) into a 16-position hydroxy macrolide compound 11107D represented by the formula (II), the DNA encoding a protein having 16-position hydroxylating enzymatic activity or ferredoxin, to a method of isolating the DNA, to a protein encoded by the DNA, a plasmid carrying the DNA, a transformant obtained by transforming using the plasmid and a method of producing a 16-position hydroxy compound by using the transformant.

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