DNA oligomers for inhibition of HIV by decreasing ribosomal fram

Details DNA oligomers for inhibition of HIV by decreasing ribosomal fram DNA oligomers for inhibition of HIV by decreasing ribosomal fram

1996-05-21

1998-01-13

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 6, 4351723, 4353201, 435366, 536 231, 536 245, C12N 1585, C12Q 168, C07H 2104

Patent

active

057078661

ABSTRACT:
The invention relates to the use of antisense DNA oligomers to decrease the occurrence of ribosomal frameshifting required for the production of HIV enzymatic proteins when translating HIV messenger RNA, which should interfere with the production of virions and disrupt HIV life cycle. The antisense DNA oligomers are complementary to regions of the RNA of the small ribosomal subunit of mammalian cells, which are involved in the control of translation fidelity.

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