DNA molecules optimized sequences that encode the IA-2IC...

Details DNA molecules optimized sequences that encode the IA-2IC... DNA molecules optimized sequences that encode the IA-2IC...

2008-03-04

2008-03-04

Ewoldt, G. R. (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S252300, C435S320100

Reexamination Certificate

active

10345307

ABSTRACT:
Otimized DNA molecules that encode human IA-2ic, wherein at least one of the codons starting at positions 2747 and 2816 of the complete IA-2 gene is CGT. Said molecules are useful for detecting insulin-dependent (type 1) diabetes mellitus, and may be fused to auxiliary proteins or peptides (for example, His-tag). RNA molecules encoded by the optimized DNA molecules, expression vectors comprising the optimized DNA molecules and cells transformed with said DNA molecules (particularlyEscherichia colicells). Also a method of producing human IA-2ic antigen that comprises growing cells transformed with the said optimized nucleic acid molecules under conditions suitable for producing said protein, the polypeptide obtained through that procedure, and an in vitro diagnostic method and a diagnostic kit using it.

REFERENCES:
Sica, M.P., et al. Biotechnol. Appl. Biochem. 2003;37:301-309.
Attwood, T.K., Science. 2000;290:471-473.
Skolnick, J. and Fetrow, J.S. TBTech. 2000;18:34-39.

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