DNA molecules having human BCL-2 gene sequences

Details DNA molecules having human BCL-2 gene sequences DNA molecules having human BCL-2 gene sequences

1991-03-19

1993-04-13

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 4351723, 436501, 436538, 436813, 530350, 5303871, 530806, 530828, 935 19, 935 24, 935 78, C07H 1700

Patent

active

052024296

ABSTRACT:
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. The translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.

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Ngan et al. (1988) the New England Journal of Medicine, vol. 318:1638.
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Tsujimoto et al. (1985) Science, vol. 228, pp. 1440-1443.
Pegoraro et al. (1984) Proc. Natl Acad Sci (USA) vol. 81, pp. 7166-7170.
Tsujimoto et al. (1984) Science, vol. 226, pp. 1097-1099.

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