DNA molecules, expression vectors and host cells expressing anti

Details DNA molecules, expression vectors and host cells expressing anti DNA molecules, expression vectors and host cells expressing anti

1995-06-06

1997-08-19

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435328, 435326, 536 2353, 5303873, 5303871, C12N 512, C12N 1500, A61K 39395

Patent

active

056587627

ABSTRACT:
DNA molecules, expression vectors, recombinant host cells and the process of preparing antigenized antibodies which have, inserted within their third complementarity determining regions, antigenic epitopes not found in immunoglobulin molecules are described.

REFERENCES:
patent: 4631191 (1986-12-01), Dale et al.
patent: 4694072 (1987-09-01), Girard et al.
patent: 5583202 (1996-12-01), Zanetti
Jones, P., et al., "Replacing the Complementarity--Determining Regions in a Human Antibody with Those From a Mouse." Nature 321:522-525 (1986).
Reichman, L., et al., "Reshaping Human Antibodies for Therapy." Nature 332:323-327 (1988).
Verhoeyen, M., et al., "Reshaping Human Antibodies: Grafting an Antilysozyme Activity." Science 239:1534-1536 (1988).
Morrison, S., "Transfectomas Provide Novel Chimeric Antibodies." Science 229:1202-1207 (1985).
Dame, J., et al., "Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sportozoite of the Human Malaria Parasite Plasmodium falciparum." Science 229:593-599 (1984).
Huston, J., et al., "Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain FV Analogue Produced in Escherichia coli." PNAS 85:5879-5883 (1988).
Zanetti, M., "Antigenized Antibodies." 355:476-477 (1992).
Tao, M., et al., "Studies of Aglycosylated Chimeric Mouse-Human IgG: Role of Carbohydrate in the Structure of Effector Functions Mediated by the Human IgG Constant Region." The Journal of Immunology 143(8):2595-2601 (1989).
Burgess, W., et al., "Possible Dissociation of the Heparin-Binding and Mitogenic Activities of Heparin-Binding (Acidic Fibroblast) Growth Factor-1 from Its Receptor-Binding Activities by Site-Directed Mutagenesis of a Single Lysine Residue" The Journal of Cell Biology 111:2129-2138 (1990).
Lazar, E., et al., "Transforming Growth Factor .alpha.: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities." Molecular and Cellular Biology 8(3):1247-1252 (1988).
Hird, V., et al., "Immunotherapy with Monoclonal Antibodies." Genes and Cancer (D. Carney an K. Sikora: Eds.) John Wiley & Sons Ltd. pp. 184-189 (1991).
Waldmann, T., "Monoclongal Antibodies in Diagnosis and Therapy." Science 252:1657-1662 (1991).
Taub, R., et al., "A Monoclonal Antibody against the Platelet Fibrinogen Receptor Contains a Sequence that Mimics a Receptor Recognition Domain in Fibrinogen." The Journal of Biological Chemistry 264(1):259-165 (1989).

Affiliated with

Also associated with

Rating

DNA molecules, expression vectors and host cells expressing anti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA molecules, expression vectors and host cells expressing anti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA molecules, expression vectors and host cells expressing anti will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1104014