DNA molecules encoding variants of tissue plasminogen activators

Details DNA molecules encoding variants of tissue plasminogen activators DNA molecules encoding variants of tissue plasminogen activators

1992-01-21

1993-12-14

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 232, 435212, 435226, 435320, 4352542, C12N 964, C12N 1500, C12N 1558

Patent

active

052701980

ABSTRACT:
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.

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