DNA molecules encoding PDGF molecules having protease resistant

Details DNA molecules encoding PDGF molecules having protease resistant DNA molecules encoding PDGF molecules having protease resistant

1994-09-09

1999-04-20

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 435243, 43525421, 4353201, 536 2351, 530399, C12N 1516, C12N 1563, C07K 14475

Patent

active

058957553

ABSTRACT:
PDGF B-chain polypeptides characterized by the substitution or deletion of a lysine or arginine residue at position 27, 28, 32, 79, 80 or 81 of native B-chain are disclosed. Also disclosed are PDGF-like proteins containing the B-chain polypeptides. The polypeptides and proteins may be produced through the use of cultured cells transfected or transformed to express DNA molecules that encode the polypeptides. The PDGF-like proteins are useful as components of cell culture media and for accelerating the healing of wounds.

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"Webster's II New Riverside University Dictionary", 1994, Houghton Mifflin Co., p. 589.
Science 237:1570, 1987. "When does homology mean something else".
Cell 50:667, 1987. Reeck et al.
Betsholtz, C. et al., Nature, 320:695-699, 1986.
Johnsson et al., "The c-sis Gene Encodes a Precursor of the B Chain of Platelet-Derived Growth Factor", EMBO Journal 3:921-928, 1984.

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