DNA molecules encoding Macaca mulatta androgen receptor

Details DNA molecules encoding Macaca mulatta androgen receptor DNA molecules encoding Macaca mulatta androgen receptor

2006-06-13

2006-06-13

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C536S023500

Reexamination Certificate

active

07060463

ABSTRACT:
The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein fromMacaca mulatta. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators ofMacaca mulattaAR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof.

REFERENCES:
patent: 5614620 (1997-03-01), Liao et al.
patent: WO 89/09791 (1989-10-01), None
Abdelgadir, et al., “Androgen Receptor Messenger Ribonucleic Acid in Brains and Pituitaries of Male Rhesus Monkeys: Studies on Distribution, Hormonal Control, and . . . ”, Bio. of Reprod. 1999, vol. 60, pp. 1251-1256.
Choong, et al., “Evolution of the Primate Androgen Receptor: A Structural Basis for Disease”, J. Mol. Evol.1998, vol. 47, No. 3, pp. 334-342.

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