Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-08-17
2010-02-02
Wegert, Sandra (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S325000, C435S320100, C536S023100, C536S023500, C530S350000
Reexamination Certificate
active
07655440
ABSTRACT:
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encodeDermacentor variabilisligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encodingD. variabilisLGIC/GluCl channels, substantially purified forms of associatedD. variabilischannel proteins and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associatedDermacentor variabilisLGIC/GluCl, which will be useful as insecticides and acaracides.
REFERENCES:
patent: 5527703 (1996-06-01), Cully et al.
patent: 5693492 (1997-12-01), Cully et al.
patent: 2021643 (1991-08-01), None
patent: 0589841 (1994-03-01), None
patent: WO 90/08828 (1990-08-01), None
patent: WO 99/07828 (1999-02-01), None
patent: WO 01/74884 (2001-10-01), None
Cully, et al, 1996, J. Biol. Chem, 271(33): 20187-20191.
Lehmann-Horn, et al., Voltage-Gated Ion Channels and Hereditary Disease, 1999, Physiol Rev 79(4); 1317.
Bech-Hansen, et al., Loss of Function Mutations in a Calcium Channel æ1- subunit gene in XP 11.23 cause incomplete X-linked congential stationary night blindness, 1998, Nature Genetics 19: 264-267.
Dent, et al., avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity inCaenorhabditis elegans, 1997, EMBO Journal, 16 (19): 5867-5879.
Xue, H., Identification of Major Phylogenetic Branches of Inhibitory Ligand-Gated Channel Receptors, 1998, J. Mol. Evol., 47: 323-333.
Kane, et al., Drug Resistant Drosophilia indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin, 2000, Proc. Natl. Acad. Sci., 97(25): 13949-12954.
Dent, et al., the genetics of ivermectin resistance in Caenorhabditis elegans, 2000, Pnas, 97(6); 2674-2679.
Lingle and Marder, : A glutamate-activated chloride conductance on a crustacean muscle, Brain Research, vol. 212, pp. 481-488 (1981).
Horseman et al., “The effects of L-glutamate on cultured insect neurons”, Neuroscience Letters, vol. 85, pp. 65-70 (1988).
Lea and Usherwood, “The Site of Action of Ibotenic Acid and the Identification of the Populations of Glutamate Receptors on Insect Muscle-Fibres”, Comp. Gen. Pharmac., vol. 4, pp. 333-350 (1973).
Cull-Candy, “Two types of Extrajunctional L-Glutamate Receptors in Locust Muscle Fibres” J. Physiol., vol. 255, pp. 449-464 (1976).
Cully, et al., “Cloning of an avermectin-sensitive glutamate-gated chloride-channel fromCaenorhabditis elegans”, Nature, vol. 371, pp. 707-711 (Oct. 20, 1994).
Arena, et al., Expression of a glutamate-activated chloride current Xenopus oocytes injected withCaenorhabiditis elegansRNA: evidence for modulation by avermectin:, Molecular Brain Research, vol. 15, pp. 339-348 (1992).
Abbott et al., MiRP1 Forms Ikr Potassium Channels with HERG and is Associated with Cardiac Arrhythmia, Cell, vol. 97, pp. 175-187 (Apr. 16, 1999).
Semenov and Pak, “Diversification of Drosophilia Chloride Channel Gene by multiple posttranscriptional mRNA modifications”, EMBL Online, Accession No. 077295 (Nov. 1, 1998).
Cully et al., Identification of a Drosophila melanogaster Glutamate-gaged Chloride Channel Sensitive to the Antiparasitc agent Avermcecin, the Journal of Biological Chemistryk vol. 271, No. 33, pp. 20187-20191 (Aug. 16, 1996).
Nikolic et al., The Human glycine Receptor Subunit a3/GLRA3 Gene Structure, Chromosomal Localization and Functional Characterization of alternative Transcripts, The Jornal of Biological Chemistry, vol. 273, No. 31, pp. 19708-19714 (Jul. 31, 1998).
Kuhse et al., Identification and Functional Expression of a Novel Ligand Binding Subunit of the Indihibitory Glycine Receptor, the Journal of Biological chemicstry, vol. 265, No. 36, pp. 22317-22320 (Dec. 25, 1990).
Cully Doris F.
Zheng Yingcong
Javrecki-Black Judy
Kowalski, Esq. Thomas
Merial Limited
Merial Limited
Wegert Sandra
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