DNA molecules encoding hybrid proteins of tissue plasminogen act

Details DNA molecules encoding hybrid proteins of tissue plasminogen act DNA molecules encoding hybrid proteins of tissue plasminogen act

1991-12-13

1993-09-07

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 232, 536 234, 435215, 435226, 4353201, 4352542, C12N 1500, C12N 1558, C12N 564, A61K 3754

Patent

active

052428192

ABSTRACT:
Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.

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