DNA molecules encoding human tissue plasminogen activator varian

Details DNA molecules encoding human tissue plasminogen activator varian DNA molecules encoding human tissue plasminogen activator varian

1992-07-09

1993-09-21

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435212, 435219, 435226, 4353201, 536 235, 536 232, C12N 964, C12N 1558, C12N 1500, C12N 510

Patent

active

052468500

ABSTRACT:
Biologically active tissue plasminogen activator (t-PA) variants with decreased clearance as compared to wild-type t-PA are prepared, including variants that have one or more amino acid alterations in at least the kringle-1 and/or kringle-2 domain(s) of the molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences and host cells transformed with the expression vectors. The variants may be used in pharmaceutical preparations to treat a vascular disease or condition, or to prevent fibrin deposition or adhesion formation or reformation in mammals.

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