DNA molecules encoding human NHL, a DNA helicase

Details DNA molecules encoding human NHL, a DNA helicase DNA molecules encoding human NHL, a DNA helicase

2008-04-22

2008-04-22

Hutson, Richard (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S183000, C435S194000

Reexamination Certificate

active

07361491

ABSTRACT:
The present invention disclosed isolated nucleic acid molecules (polynucleotides) which encode NHL, a putative DNA helicase. The present invention in turn relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding NHL, substantially purified forms of associated NHL, associated mutant proteins, and methods associated with identifying compounds which modulate NHL, which will be useful in the treatment of various neoplastic disorders. Both a genomic clone containing regulatory and intron sequences, as well as the exon structure and open reading frame of human NHL are disclosed.

REFERENCES:
patent: 5466576 (1995-11-01), Schulz et al.
patent: 5843737 (1998-12-01), Chen et al.
patent: 5888792 (1999-03-01), Bandman et al.
Ngo et al., Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Ngo, Thomas et al. “Computational Complexity, Protein Structure Prediction, and the Levintnal Paradox” in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Genbank Accession No. AL080127, Wambutt, R. et al. Direct Submission, (1999).
Genback Accession No. AB029011, Kikuno, R. et al. “Prediction of the coding sequences of unidentified human gene. XIV. The complete sequences of 100 new cDNA clones from brain which code for large protens in vitro”, (1999).
Bai, Chang et al. “Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster”. PNAS, vol. 97, No. 3, Feb. 1, 2000, pp. 1230-1235.
Zhou, J.-Q. et al. “Piflp Helicase, a Catalytic Inhibitor of Telomerase in Yeast”. Science, vol. 289, Aug. 4, 2000, pp. 771-774.
Naumovski, Louie et al. “RAD3 Gene ofSaccharomyces cerevisiae: Nucleotide Sequence of Wild-Type and Mutant Alleles, Transcript Mapping, and Aspects of Gene Regulation”. Molecular and Cellular Biology, Jan. 1985, pp. 17-26.
Reynolds, Paul et al. “The nucleotide sequence of the RAD3 gene ofSaccharomyces cerevisia: a potential adenine nucleotide binding amino acid sequence and a nonessential acidic carboxyl terminal region”. Nucleic Acid Research, vol. 13, No. 7, 1985, pp. 2357-2372.
Weber, Christine A. et al. “ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3”, The EMBO Journal, vol. 9, No. 5, 1990, pp. 1437-1447.
Tuteja, Narendra et al. “Inhibition of DN Unwinding and ATPase Activities of Human DNA Helicase II by Chemotherapeutic Agents”, Biochemical and Biophysical Research COMM., vol. 236, 1997, pp. 636-640.
Lun, Lapman et al. “Antihelicase action of CI-958, a new drug for prostate cancer”. Cancer Chemother Pharmacol, vol. 42, 1998, pp. 447-453.

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