Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-10-24
1996-03-26
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 234, 536 232, 435223, 435 697, 435 698, 435 699, 4353201, 935 48, 935 10, 935 14, C12N 1562, C12N 1563, C12N 1557
Patent
active
055019757
ABSTRACT:
The invention concerns novel DNA molecules encoding a modified, endoplasmic reticulum-located "dibasic processing endoprotease" and the use of said endoplasmic reticulum-located "dibasic processing endoprotease" for the correct processing of heterologous polypeptides in transformed hosts.
REFERENCES:
Pelham, H. R. B., "Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment", The EMBO Journal, 7(4): 913-918 (1988).
Barr et al., J. Biol. Chem., 263:16471-16478 (1988).
Broach et al., Gene, 8:121-133 (1979).
Dean et al., Biological Abstract No. 91695, vol. 90, pp. 1006-1007 (1990).
Felgner et al., Proc. Natl. Acad. Sci. USA, 84:7413-7417 (1987).
Fuller et al., Proc. Natl. Acad. Sci. USA, 86:1434-1438 (1989).
Fuller et al., Science, 246:482-485 (1989).
Graham et al., Virology, 52:456-467 (1973).
Hinnen et al., "Heterologous Gene Expression in Yeast" in Yeast Genetic Engineering, pp. 193-213 (1989) Butterworths Publishers, Stoneham.
Klebe et al., Gene, 25:333-341 (1983).
Kurjan et al., Cell, 30:933-943 (1982).
Laemmli et al., Nature, 227:680-685 (1970).
Mizuno et al., Biochem. Biophys. Res. Commun., 156:246-254 (1988).
Pfeffer et al., Ann. Rev. Biochem., 56:829-852 (1987).
Rothstein, Methods Enzymol., 194:281-302 (1991).
Sanger et al., Proc. Natl. Acad. Sci. USA, 74:5463-5467 (1977).
Steube et al., Eur. J. Biochem., 198:651-657 (1991).
Von Heijne, Nucleic Acids Research, 14(11) 4683-4690 (1986).
Zoller et al., Methods in Enzymology, 154:329-350 (1987).
Mullenbach et al., Fed. Proc. 42:434 (abstract) (1983).
Chaudhuri et al., FEBS Letters 304:41-45 (1992).
Mitani et al., Yeast, 6:127-137 (1990).
Dean et al. J. Cell. Biol. vol. 111, Aug. 1990, pp. 369-377.
Chaudhuri Bhabatosh
Riezman Howard
Seeboth Peter
Stephan Christine
Ciba-Geigy Corporation
Elmer James Scott
Hendricks Keith D.
Patterson Jr. Charles L.
LandOfFree
DNA molecules encoding an ER-located endoprotease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA molecules encoding an ER-located endoprotease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA molecules encoding an ER-located endoprotease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-915121