Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-03-03
1995-02-14
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352542, 4353201, 536 232, 536 241, C12P 2102, C12N 1581, C12N 1552, C12N 119
Patent
active
053895258
ABSTRACT:
The invention relates to DNA-molecules comprising DNA-sequences encoding control regions and the structural gene for a protein having formate dehydrogenase (FMDH) activity. Said DNA-molecules may be combined with DNA-sequences encoding foreign genes so as to bring these genes under the stringent control of the regulation of the FMDH regulatory sequences and/or may be combined to DNA-sequences coding for secretory signals. The invention further relates to recombinant vectors containing said DNA-molecules and micro-organisms containing said vectors or DNA-molecules. Furthermore, the invention relates to a process for producing a useful substance by producing this substance by culturing said micro-organisms and recovering the substance.
REFERENCES:
patent: 4855231 (1989-08-01), Stroman et al.
patent: 4876197 (1989-10-01), Burke et al.
patent: 4886750 (1989-12-01), Bertola et al.
Ledeboer, A. M., et al., "Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha," Nucleic Acids Research, vol. 13, No. 9, pp. 3063-3081 (1985).
Janowicz, Z. A., et al., "Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha," Nucleic Acids Research, vol. 13, No. 9, 3043-3062 (1985).
Allais, J. J., et al., "Oxidation of Methanol by the Yeast Pichia pastoris. Purification and Properties of the Formate Dehydrogenase," Agric. Biol. Chem., 47 (11), pp. 2547-2554 (1983).
Cregg, J. M., et al., "High-Level Expression and Efficient Assembly of Hepatitis B Surface Antigen in the Methylotrophic Yeast, Pichia Pastoris," Bio Technology, vol. 5, pp. 479-485 (May 1987).
Hinnen, A., "Yeast As an Expression System for Heterologous Proteins," Elsevier Science Publishers B. V., Amsterdam (1987).
Tschopp, J. F., et al., "Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris," Nucleic Acids Research, vol. 15, No. 9, pp. 3859-3876 (1987).
Roa, Michele, et al., "Biosynthesis of peroxisomal enzymes in the methylotrophic yeast Hansenula polymorpha", Proc. Natl. Acad. Sci. U.S.A., vol. 80, pp. 6872-6876 (Nov. 1983).
Ellis, S. B., et al. "Isolation of Alcohol Oxidase and Two Other Methanol Regulatable Genes from the Yeast Pichia pastoris", Molecular and Cellular Biology, pp. 1111-1121 (May 1985).
Shuber, A. P. et al., "Cloning, Expression, and Nucleotide Sequence of the Formate Dehydrogenase Genes from Methanobacterium fromicicum", Journal of Biological Chemistry vol. 261, No. 28: pp. 12942-12947 (Oct. 1986).
Zioni, F., "Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogen-lyase-linked) from Escherichia coli", Proc. Natl. Acad. Sci. U.S.A., vol. 83, pp. 4650-4654 (Jul. 1986).
An International Journal on Morphology, Physiology, Genetics, and Ecology of Microorganisms, Journal of Basic Microbiology, vol. 28, 1988.
M. A. Gleeson and P. E. Sudbery, The Methylotrophic Yeasts, Yeast, vol. 4: 1-15 (1988).
Shuber et al. (1986) "Formate dehydrogenase genes from Methanobacterium formicium," vol. 261, JBC, pp. 12942-12947.
Avilova et al. (1985) "Formate dehydrogenase from yeast," vol. 152, E. J. of Biochem, pp. 657-662.
Janowicz et al. (1985) "DAS gene from yeast H. polymorpha," vol. 13, NAR, pp. 3042-3062.
Miyanohara et al. (1983), "Expression of hepatitis B surface antigen gene in yeast," vol. 80, PNAS, pp. 1-5.
Shavlovskii et al. (1987) "Participation of Iron in the Regulation of Formate Dehydrogenase," vol. 56, Mikrobiologiya, pp. 181-185.
Hollenberg Cornelius P.
Janowicz Zbigniew
Ketter James
Rhein Biotech
Schwartz Richard A.
LandOfFree
DNA-molecules coding for FMDH control regions and structural gen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA-molecules coding for FMDH control regions and structural gen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA-molecules coding for FMDH control regions and structural gen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-287172