DNA molecules and vectors encoding clavulanic acid biosynthesis

Details DNA molecules and vectors encoding clavulanic acid biosynthesis DNA molecules and vectors encoding clavulanic acid biosynthesis

1998-03-09

2000-03-14

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4352523, 43525233, 43525235, 4353201, 435375, 435471, 435476, 435 6, 536 232, 536 237, C12N 1574, C12N 1500, C07H 2104, C12Q 168

Patent

active

060371560

ABSTRACT:
DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulanic acid and may be used to improve the yield of clavulanic acid produced by clavulanic acid-producing organisms such as S. clavuligerus ATCC 27064.

REFERENCES:
Communication of Notice of Opposition from European Patent Office, including Facts and Arguments, against EP 0 349 121 B1 (Ref. AE herein) by Biochemie GmbH.
F. Malpartida and D.A. Hopwood, "Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic . . . ," Nature, vol. 309, 462-4 (May 31, 1984).
C.R. Bailey et al., "Cloning a Streptomyces clavuligerus genetic locus involved in clavulanic acid biosynthesis," Bio/Technology, Sep. 1984, 808-811.
J. Romero et al., "Isolation and biochemical characterization of Streptomyces clavuligerus mutants in the biosynthesis . . . ," Appl. Microbiol. Biotechnol, 1988, 27:510-516.
J. Romero et al., "Dissociation of cephamycin and clavulanic acid biosynthesis . . . ," Appl. Microbiol. Biotechnol., 1984, 20:318-325.
ATCC Catalogue of Bacteria, Phages & rDNA Vectors, 16.sup.th ed., 1985, p. 181.

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