DNA Molecules

Details DNA Molecules DNA Molecules

2005-07-26

2005-07-26

Nolan, Patrick J. (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023700, C536S024100, C530S358000, C435S004000, C435S007100, C435S069200, C435S252300, C435S233000, C436S501000

Reexamination Certificate

active

06921813

ABSTRACT:
The present invention provides novel nucleic acid molecules coding for sigma subunits ofMycobacterium tuberculosisRNA polymerase. It also relates to polypeptides, referred to as SigA and SigB, encoded by such nucleic acid molecules, as well as to vectors and host cells transformed with the said nucleic acid molecules. The invention further provides screening assays for compounds which inhibit the interaction between a sigma subunit and a core RNA polymerase.

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Predich et al., Molecular Microbiology, vol. 15:355-366, Feb. 1995.
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Doukhan, et al., Gene 165, 67-70 (1995).
Collins, et al., Proc. Natl. Acad. Sci. USA 92, 8036-8040 (1995).

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