Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-07-23
2000-07-18
Achutamurthy, Ponnathapu
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, A61K 3800, C07K 14435, C07K 1447
Patent
active
060907835
ABSTRACT:
A DNA molecule having a gene expression repressing function derived from human T-cell leukemia virus type I (HTLV-I) existing in a region which is missing in a mutant provirus that is expressing p21Xm RNA but exists in the genome of a complete provirus, and a plasmid including the DNA molecule are provided. Furthermore, a novel protein (TRP-1) which specifically binds to U5RE and a structural gene for the protein is provided, which can be useful for elucidation of the transcription repression activity and elucidation of the oncogenesis mechanism of neurocytes, in which a transcriptional repressive region (U5RE) existing in the U5 region of human T-cell leukemia virus type I gene LTR is involved. Furthermore, an expression vector including the gene, a transformant into which the expression vector is introduced, and a process for producing the TRP-1 protein using the transformant are provided.
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Igarashi Hisanaga
Okumura Kouichi
Orita Satoshi
Saiga Akihiko
Sakaguchi Gaku
Achutamurthy Ponnathapu
Haley, Jr. James F.
Monshipouri Maryam
Shionogi & Co. Ltd.
Weissman Jennifer T.
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