Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-05
1999-12-28
Campbell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 691, 4353201, 435325, 435863, 435455, 514 12, 530825, A61K 4800
Patent
active
060082011
ABSTRACT:
The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis an ability to enter mammalian cells and to survive within macrophages. The protein encoded by this gene fragment is useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.
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R.R. Isberg, et al., "A single genetic locus encoded by Yersinia Pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12", Nature 317:262-64 (1985).
Arruda et al., "Cloning of a Mycobacterium tuberculosis Gene Necessary for Invasion of Cultured Epithelial Cells," Abstracts of the General Meeting, 92:41 (1992).
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Arruda, et al., "Cloning of an M. tuberculosis DNA Fragment Associated with Entry and Survival Inside Cells," Science, 261:1454-1457 (1993).
Horwitz, et al., "Protective Immunity Against Tuberculosis Induced by Vaccination With Major Extracellular Proteins of Mycobacterium tuberculosis," Proc. Natl. Acad. Sci. USA, 92:1530-34 (1995).
Campbell Bruce R.
Cornell Research Foundation Inc.
Nguyen Dave Trong
LandOfFree
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