DNA methylation specific signal amplification

Details DNA methylation specific signal amplification DNA methylation specific signal amplification

2008-01-10

2009-10-27

Kim, Young J (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

07608402

ABSTRACT:
This invention is related to a method for rapidly detecting gene specific methylation through signal amplification using the epi-barcode after hybrid capture of the methylated DNA sequence.

REFERENCES:
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patent: WO 02101353 (2002-12-01), None
Kang et al., “Highly Sensitive, Specific Detection of O6-Methylguanine, O4-Methylthymine, and O4-Ethylthymine by the Combination of High-Performance Liquid Chromatography Prefractionation, 32P Postlabeling, and Immunoprecipitation,” Cancer Research, Oct. 1992, vol. 52, pp. 5307-5312.
Needels et al., “Generation and screening of an oligonucleotide-encoded synthetic peptide library,” PNAS, USA, Nov. 1993, vol. 90, pp. 10700-10704.
Sano et al., “Detection of heavy methylation in human repetitive DNA subsets by a monoclonal antibody againse 5- methylcytosine,” Biochimica et Biophysica, Acta, 1988, vol. 951, pp. 157-165.

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