DNA, host cell and vector encoding a protein with cytokine inhib

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 695, 435 6952, 4353201, 4352523, 435325, 435335, 435 691, C07H 2104, C12P 2102, C12N 1500, C12N 120

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active

058745610

ABSTRACT:
The present invention is directed to DNA, host cells and a vector encoding a protein with cytokine inhibitory activity, particularly IL-1 inhibitory activity. The protein encoded by the DNA of the present invention is particularly useful as an IL-1 antagonist.

REFERENCES:
patent: 5011779 (1991-04-01), Newman et al.
patent: 5075222 (1991-12-01), Hannum et al.
patent: 5180812 (1993-01-01), Dower et al.
patent: 5359032 (1994-10-01), Dayer et al.
Buchan et al., "Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1.alpha., " Clin. Exp. Immunol. 73:449-455 (Mar. 24, 1988).
Carter, et al., "Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein," Nature 344:633-638 (Apr. 12, 1990).
Cominelli, et al., "Interleukin 1 (IL-1) Gene Expression, Synthesis, and Effect of Specific IL-1 Receptor Blockade in Rabbit Immune Complex Colitis," J. Clin. Invest., 86:972-980 (Sep. 1990).
Cotran, et al., "Induction and Detection of a Human Endothelial Activation Antigen In Vivo," J. Exp. Med., Brief Definitive Report, 164:661-666 (Aug. 1986).
Dinarello, et al., "Multiple Biological Activities of Human Recombinant Interleukin 1," J. Clin. Invest., 77:1734-1739 (Jun. 1986).
Dorland's Illustrated Medical Dictionary, 24th Ed. W.B. Saunders Company, Philadelphia and London, p. 760 (1965).
Eisenberg, et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist," Nature, 343:341-346, (Jan. 25, 1990).
Fanslow, et al., "Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor," Science, 248:739-742, (May 1990).
Gosset, et al., "Production of an Interleukin-1 Inhibitor Factor by Human Alveolar Macrophages from Normals and Allergic Asthmatic Patients," Am. Rev. Respir. Dis., 138:40-46 (1988).
Hannum, et al., "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor," Nature, 343:336-339 (Jan. 25, 1990).
Maliszewski, et al., "Cytokine Receptors and B Cell Functions -1. Recombinant Soluble Receptors Specifically Inhibit IL-1-and IL-4-Induced B Cell Activities in Vitro," The Journal of Immunology, 144:3028-3033, No. 8 (Apr. 15, 1990).
Oppenheim, et al., "There is More Than One Interleukin 1," Immunology Today, Reviews, 7:45-56 No. 2 (1986).
Palaszynski, "Synthetic C-Terminal Peptide of IL-1 functions as a Binding Domain As Well As An Antagonist For The IL-1 Receptor," Biochemical and Biophysical Research Communications, 147:204-211, No. 1 (Aug. 31, 1987).
Seckinger, et al., "A Urine Inhibitor of Interleukin 1 Activity Affects Both Interleukin 1.alpha. and 1.beta. But Not Tumor Necrosis Factor .alpha.," The Journal of Immunology, 139:1541-1545, No. 5, (Sep. 1, 1987).
Simpson, et al., "Reduction of Experimental Canine Myocardial Reperfusion Injry by a Monoclonal Antibody (Anti-Mo 1, Anti-CE11b) That Inhibits Leukocyte Adhesion," J. Clin. Invest., 81:624-629, (Feb. 1988).
Vedder, et al., "A Monoclonal Antibody to the Adherence-promoting Leukocyte Glycoprotein, CD18, Reduces Organ Injury and Improves Survival from Hemorrhagic Shock and Resuscitation in Rabbits," J. Clin. Invest., 81:939-944, (Mar. 1988).

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