DNA fragments, probes and amplification primers of the 65 kD ant

Details DNA fragments, probes and amplification primers of the 65 kD ant DNA fragments, probes and amplification primers of the 65 kD ant

1993-08-12

1996-12-31

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 237, 536 2433, C07H 2104

Patent

active

055895859

ABSTRACT:
Nucleotide fragment of DNA, whose nucleotide sequence is included in the gene of the species of the genus Mycobacterium, coding for the 65-kD mycobacterial antigen, containing regions which are homologous in practically all species of the genus Mycobacterium, and at least one species-specific variable region, characterized in that said fragment is chosen from fragments whose nucleotide sequences possess at least 70% homology, and preferably at least 85% homology, with a predetermined sequence or its complementary sequence, said predetermined sequence beginning at nucleotide 438 and ending at nucleotide 751 of said gene coding for said antigen of all species of mycobacteria except for the species M. tuberculosis, M. bovis BCG, M. avium, M. paratuberculosis, M. fortuitum, M. malmoense, M. leprae, M. kansaii and M. marinurn.

REFERENCES:
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Engers, H. D., et al., "Results of a World Health Organization-Sponsored Workshop to Characterize Antigens Recognized by Mycobacterium-Specific Monoclonal Antibodies," Infection and Immunity, vol. 51, 1986, pp. 718-720.
Kiehn, Timothy E., et al., "Infections Caused by Mycobacterium avium Complex in Immunocompromised Patients: Diagnosis by Blood Culture and Fecal Examination, Antimicrobial Susceptibility Tests, and Morphological and Seroagglutination Characteristics," Journal of Clinical Microbiology, vol. 21, No. 2, Feb. 1985, pp. 168-173.
Macher, Abe M. M.D. et al., "Bacteremia Due to Mycobacterium avium-intracellulare in the Acquired Immunodeficiency Syndrome," Annals of Internal Medicine, 1983:99:782-785.
Ellis, John, "Cellular biochemistry, Proteins as Molecular Chapaerones," Nature, vol. 328, 30 Jul. 1987, pp. 378-379.
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Young, Richard A., et al., "Dissection of Mycobacterium tuberculosis antigens using recombinant DNA," Proc. Natl. Acad. Sci. USA, vol. 82, pp. 2583-2587, May 1985.
Young, Richard A., et al., "Genes for the Major Protein Antigens of the Leprosy parasite Mycobacterium leprae, "Nature, vol. 316, 1 Aug. 1985, pp. 450-452.
Lu, Melvin C., et al., "Genes for Immunodominant Protein Antigens Are Highly Homologous in Mycobacterium tuberculosis, Mycobacterium Africanum, and the Vaccine Strain Mycobacterium Bovis BCG," Infection and Immunity, Oct. 1987, vol. 55, No. 10, pp. 2378-2382.
Husson, Robert N., et al., "Genes for the Major Protein Antigens of Mycobacterium Tuberculosis: The etiologic agents of tuberculosis and leprosy share an immunodominant antigen," Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1679-1683, Mar. 1987.
Andersen, Ase Bengard, et al., "Isolation and Characterization of Recombinant Lambda gt11 Bacteriophages Expressing Eight Different Mycobacterial Antigens of Potential Immunological Relevance," Infection and Immunity, May 1988, vol. 56, No. 5, pp. 1344-1351.
Shinnick, Thomas M., "The 65-Kilodalton Antigen of Mycobacterium tuberculosis," Journal of Bacteriology, Mar. 1987, vol. 169, No. 3, pp. 1080-1088.
Thole, Jelle E., et al., "Cloning of Mycobacterium bovis BCG DNA and Expression of Antigens in Escherichia coli," Infection and Immunity, Dec. 1985, vol. 50, No. 3, pp. 800-806.
Mehra, Vuay, et al., "Efficient Mapping of Protein Antigenic Determinants," Proc. Natl. Acad. Sci. USA, vol. 83, pp. 7013-7017, Sep. 1986.
Hance, A. J., et al., "Detection and Identification of Mycobacteria by Amplification of Mycobacterial DNA," Molecular Microbiology, (1989) 3(7), pp. 843-849.
Thole, Jelle E. R., et al., "Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia coli K-12," Infection and Immunity, vol. 55, No. 6, Jun. 1987, pp. 1466-1475.
Sjobring, Ulf., et al., "Polymerase Chain Reaction for Detection of Mycobacterium Tuberculosis," Journal of Clinical Microbiology, vol. 28, No. 1, Oct. 1990, pp. 2200-2204.
Saiki, Randall K., et al., "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase," Science, vol. 239, pp. 487-491.
Stead, et al., "Changing Faces of Clinical Tuberculosis," Mycobacterium tuberculosis, Interacting with the Immune System, Plenum, NY 1988, pp. 371-388.
1988 Stratagere Catalog, p. 39.

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