DNA fragments of mycobacteria, amplification primers hybridizati

Details DNA fragments of mycobacteria, amplification primers hybridizati DNA fragments of mycobacteria, amplification primers hybridizati

1996-08-16

1998-12-15

Houtteman, Scott W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2432, C07H 2104

Patent

active

058499016

ABSTRACT:
Nucleotide fragment of DNA, whose nucleotide sequence is included in the gene of the species of the genus Mycobacterium, coding for the 65-kD mycobacterial antigen, containing regions which are homologous in practically all species of the genus Mycobacterium, and at least one species-specific variable region, characterized in that said fragment is chosen from fragments whose nucleotide sequences possess at least 70% homology, and preferably at least 85% homology, with a predetermined sequence or its complementary sequence, said predetermined sequence beginning at nucleotide 438 and ending at nucleotide 751 of said gene coding for said antigen of all species of mycobacteria except for the species M. tuberculosis, M. bovis BCG, M. avium, M. paratuberculosis, M. fortuitum, M. malmoense, M. leprae, M. kansaii and M. marinum.

REFERENCES:
Hance et al., Molecular Microbiology 3(7):843-849.
Wayne et al., Family Mycobacteriaceae Chester, 1897, 63.sup.AL* , Section 16, Mycobacteria, Bergey's Manual of Systemic Bacteriology, vol. 2, pp. 1436-1457, (1986).
Styblo, K. MD., "The Kellersberger Memorial Lecture, 1982.sup.1 , Tuberculosis and its Control: Lessons to be learned from Past Experience, and Implifications for Leprosy Control Programmes," Ethiop. Med. J., 21, pp. 101-122.
Engers, H.D., et al., "Results of a World Health Organization-Sponsored Workshop to Characterize Antigens Recognized by Mycobacterium-Specific Monoclonal Antibodies," Infection and Immunity, vol. 51, pp. 718-720, (1986).
Kiehn, Timothy E., et al., "Infections Caused by Mycobacterium avium Complex in Immunocompromised Patients: Diagnosis by Blood Culture and Fecal Examination, Antimicrobial Suspectibility Tests, and Morphological and Seroagglutination Characteristics," Journal of Clinical Microbiology, vol. 21, No., 2, pp. 168-173, (1985).
Macher, Abe M. M.D. et al., "Bacteremia Due to Mycobacterium avium-intracellular in the Acquired Immunodeficiency Syndrome, " Annals of Internal Medicine, vol. 99, pp. 782-785, (1983).
Ellis, John, "Cellular biochemistry, Proteins as Molecular Chapaerones," Nature, vol. 328, pp. 378-379, (1987).
Clark-Curtiss, Josephine E., et al., "Molecular Analysis of DNA and Construction of Genomic Libraries of Mycobacterium leprae," Journal of Bacteriology, vol. 161, No. 3, pp. 1093-1102, (1985).
Young, Richard A., et al., "Dissection of Mycobacterium tuberculosis antigens using recombinant DNA," Proc. Natl. Acad. Sci. USA, vol. 82, pp. 2583-2587, (1985).
Young, Richard A., et al., "Genes for the Major Protein Antigens of the Leprosy parasite Mycobacterium leprae," Nature, vol. 316, pp. 450-452, (1985).
Lu, Melvin C., et al., "Genes for Immunodominant Protein Antigens are Highly Homologous in Mycobacterium Tuberculosis, Mycobacterium Africanum, and the Vaccine Strain Mycobacterium Bovis BCG," Infection and Immunity, vol. 55, No. 10, pp. 2378-2382, (1987).
Husson, Robert N., et al., "Genes for the Major Protein Antigens of Mycobacterium Tuberculosis: The etiologic agents of tuberculosis and leprosy share an immunodominant antigen," Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1679-1683, (1987).
Andersen, Ase Bengard, et al., "Isolation and Characterization of Recombinant Lambda gt11 Bacteriophages Expressing Eight Different Mycobacterial Antigens of Potential Immunological Relevance," Infection and Immunity, vol. 56, No. 5, pp. 1344-1351, (1988).
Shinnick, Thomas M., "The 65-Kilodalton Antigen of Mycobacterium tuberculosis," Journal of Bacteriology, vol. 169, No. 3, pp. 1080-1088, (1987).
Thole, Jelle E., et al., "Cloning of Mycobacterium bovis BCG DNA and Expression of Antigens in Escherichia coli, " Infection and Immunity, vol. 50, No. 3, pp. 800-806, (1985).
Mehra, Vuay, et al., "Efficient Mapping of Protein Antigenic Determinants," Proc. Natl. Acad. Sci. USA, vol. 83, pp. 7013-7017, (1986).
Hance, A. J., et al., "Detection and Identification of Mycobacteria by Amplification of Mycobacterial DNA," Molecular Microbiology, vol. 3, No. 7, pp. 843-849, (1989).
Thole, Jelle E. R., et al., "Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia coli K-12," Infection and Immunity, vol. 55, No. 6, pp. 1466-1475, (1987).
Sjobring, Ulf., et al., "Polymerase Chain Reaction for Detection of Mycobacterium Tuberculosis," Journal of Clinical Microbiology, vol. 28, No. 1, pp. 2200-2204, (1990).
Saiki, Randall K., et al., "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase," Science, vol. 239, pp. 487-491, (1988).
Stead, et al., "Changing Faces of Clinical Tuberculosis," Mycobacterium tuberculosis, Interacting with the Immune System, Mycobacterium tuberculosis. Interactions with the Immune System, pp. 371-388, (1988).
1988 Stratagene Catalog, p. 39.

Affiliated with

Also associated with

Rating

DNA fragments of mycobacteria, amplification primers hybridizati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA fragments of mycobacteria, amplification primers hybridizati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA fragments of mycobacteria, amplification primers hybridizati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1459363