Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-11-18
1998-06-30
Scheiner, Laurie
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 241, 536 231, 4241881, C07H 2104, C07H 2102
Patent
active
057736022
ABSTRACT:
A novel human immunodeficiency virus type 1 (HIV-1) isolate, designated lymphadenopathy-associated virus strain MAL, or LAV.sub.MAL, was molecularly cloned and characterized. Nucleotide sequence analysis demonstrated that the viral genome of LAV.sub.MAL is 9229 nucleotides long. This retrovirus contains the canonical gag, pol, and env genes, as well as ancillary genes encoding Vif (or Q), Vpr (or R), Tat (or S), and Nef (or F). This virus differs significantly, at both the nucleotide and amino acid sequence levels, from prototypical HIV isolates (e.g., HTLV-III, LAV.sub.BRU, and ARV). DNA fragments corresponding to the various gene products and regulatory regions are disclosed. These fragments are useful, inter alia, as probes in diagnostic assays and for the generation of recombinant proteins.
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Alizon Marc
Montagnier Luc
Sonigo Pierre
Wain-Hobson Simon
Institut Pasteur
Parkin Jeffrey S.
Scheiner Laurie
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