DNA for the production of multimeric hemoglobins

Details DNA for the production of multimeric hemoglobins DNA for the production of multimeric hemoglobins

1995-05-31

1998-04-14

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351721, 4352523, 43525411, 4353201, 435325, 530385, 536 235, C12P 2102, C07H 2104, C12N 1512, C07K 14805

Patent

active

057390118

ABSTRACT:
DNA molecules which encode pseudodimeric globin-like polypeptides with an asymmetric cysteine mutation suitable for crosslinking two tetramers, or which encode pseudooligomeric globin-like polypeptides comprising four or more globin-like domains, are useful in the preparation of multimeric hemoglobin-like proteins.

REFERENCES:
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4336248 (1982-06-01), Bonhard
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4529719 (1985-07-01), Tye
patent: 4551433 (1985-11-01), Deboer
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4769326 (1988-09-01), Rutter
patent: 4777244 (1988-10-01), Bonhard
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5173426 (1992-12-01), Fischer et al.
patent: 5545727 (1996-08-01), Hoffman et al.
Fermi, G. & Perutz, M.F./Atlas of Molecular Structures in Biology/2. Haemoglobin and Myoglobin/Clarendon Press/Oxford/(1981), Entire Text.
Bunn, H.F. & Forget, B.G./Hemoglobin: Molecular, Genetic and Clinical Aspects/(1986), W.B. Saunders Publishing/Philadelphia, PA/Ed. John Dyson/Entire Text.
Looker, D. et al/Expression of Recombinant Human Hemoglobin in Escherichia coli/Methods in Enzymology/(In Press).
Steadman, J.H. et al/Diopathic Heinze Body Anaemia: HB-Bristol (.beta.67 (E11) VAL.fwdarw.ASP)/British J. of Haematology/(1970), 18, 435-446.
Anderson, N.L. & Perutz, M.F./Site of the Amino-Acid Substitution in Haemoglobin Seattle (.alpha..sup.A.sub.2 .beta..sup.70.sub.2.sup.ASP)/Nature New Biology/(1973), 243, 274-275.
Cohen, C. & Parry, D.A.D./.alpha.-Helical Coiled Coils and Bundles: How to Design an .alpha.-Helical Protein/Proteins: Structure, Function, and Genetics/(1990), 7, 1-15.
Yeager, A.M. et al/Hemoglobin Cheverly: An Unstable Hemoglobin Associated with Chronic Mild Anemia/Pediatr. Res./(1983), 17, 503-507.
Yabuki, A,. et al/Characterization of a Pyridoxalated Hemoglobin-Polyoxyethylene Conjugate as a Physiologic Oxygen Carrier/Transfusion/(1990), 30 (5), 516-520.
Dimarchi, R. et al/Chemical Synthesis of Human Epidermal Growth Factor (EGF) and Human Type .alpha. Transforming Growth Factor (TGF.alpha.)/Peptides Chemistry and Biology/(1988), Ed. G.R. Marshall/Escom. Leiden/202-203.
Dowling, S. et al/A Clinical Study of Fluosol and Hyperbaric Oxygen as an Adjunct to Radiation Therapy/Biomat. Art. Cells. Immobil. Biotech./(1991), 19, 377.
Dickerson, R.E. & Geis, I./Evolution of the Oxygen Carriers/Hemoglobin, Structure, Function, Growth & Pathology/(1983)/Benjamin Cummings Publishing Co. CA/66-114.
Kavanaugh, M.P. et al/Affinity Labeling of Hemoglobin with 4,4'-Diisothiocyanostilbene-2, 2'-Disulfonate: Covalent Cross-Linking in the 2,3-Diphosphoglycerate Binding Site/Biochemistry(1988). 27. 1804-1808.
Hallewel, R.A. et al/Genetically Engineered Polymers of Human CuZn Superoxide Dismutase-Biochemistry and Serum Half-Lives/J. of Biol. Chem./(1989), 264(9), 5260-5268.
Zagloul, T.I. & Doi, R.H./Translational Coupling in Eschericha coli of a Heterologous Bacillus subtilis-Escherichia coli Gene Fusion/J. of Bacteriology./(1986), 168(2), 1033-1035.
Imai, K. et al/Studies on the Function of Abnormal Hemoglobins-II. Oxygen Equilibrium of Abnormal Hemoglobins: Shimoneseki, Ube II, Hikari, Gifu, and Agenogi/Biochemimica et Biophysica ACTA/(1970), 200, 197-202.
Bonaventura, J. & Riggs, A./Hemoglobin Kansas, A Human Hemoglobin with a Neutral Amino Acid Substitition and an Abnormal Oxygen Equilibrium/J. of Biol. Chem/(1968). 243(5), 980-991.
Ahern, E. et al/Haemoglobin Caribbean .beta.91 (F7) LEU.fwdarw.ARG: A Mildly Unstable Haemoglobin with a Low Oxygen Affinity/FEBS Letters/(1976),69(1), 99-102.
Tatsis, B. et al/Hemoglobin PYRGOS .alpha..sub.2 .beta..sub.2 .sup.83(EF7)GLY.fwdarw.ASP : A New Hemoglobin Variant in Double Heterozygosity with Hemoglobin S/Blood/(1976), 47(5), 827-832.
Sugihara, J. et al/ Hemoglobin Rahere, A Human Hemoglobin Variant with Amino Acid Substitution at the 2,3-Diphosphoglycerate Binding Site/J. Clin. Invest./(1985), 76, 1169-1173.
Hong, G.R. et al/Hemoglobin Nigeria (.alpha.-81 SER.fwdarw.CYS): A New Variant Associated with .alpha.-Thalassemia/Blood/(1980), 55(1), 131-137.
Lewin, B./The Messenger RNA Template/Genes/(1983), Ed. Cell/Publisher-J. Wiley & Sons, NY Chapter 9, 143-162.
Ranney, H.M. et al/Haemoglobin New York/Nature/(1967), 876-878.
Nagel, R.L. et al/Hemoglobin Beth Israel, A Mutant Causing Clinically Apparent Cyanosis/The New England J. of Med./(1976), 295(3), 125-130.
King, M.A.R./An Unstable Haemoglobin with Reduced Oxygen Affinity: Haemoglobin Peterborough, .beta.III (G.sub.13) Valine.fwdarw.Phenylalanine, Its Interaction with Normal Haemoglobin and with Haemoglobin Lepore/Brit. J. of Haema./(1972), 22, 125-134.
Moo-Penn, W.F. et al/Hemoglobin Presbyterian: .beta.108 (G10) Asparagine.fwdarw.Lysine. A Hemoglobin Variant with Low Oxygen Affinity/FEBS Letters/(1978), 92(1), 53-56.
Konotey-Ahulu, F.I.D. et al/Haemoglobin Korle-Bu (.beta.73, Aspartic Acid.fwdarw.Asparagine)/J. Med. Genet./(1968),5, 107-111.
Merault, G. et al/Hemoglobin Roseau-Pointe a Pitre .alpha..sub.2 .beta..sub.2 90 (F6) GLU.fwdarw.GLY: A New Hemoglobin Variant with Slight Instability and Low Oxygen Affinity/FEBS Let./(1985), 184(1), 10-13. Variant with Decreased Oxygen Affinity/Hemoglobin/(1987), 11(5), 453-464.
Stamatoyannopoulos, G. et al/Physiologic Implications of a Hemoglobin with Decreased Oxygen Affinity (Hemoglobin Seattle)/The New England J. of Med./(1969), 281(17), 915-919.
Degrado, W.F. et al/Protein Design, A Minimalist Approach/Science/(1989), 243, 622-628.
Semchuk, P.D. et al/Synthetic .alpha.-Helical Model Proteins: Contribution of Hydrophobic Residues to Protein Stability/Peptides Chemistry, Structure and Biology/Ed. J.E. Rivier & G.R. Marshall/Publisher, Escom-Leiden/(1990), 566-570.
Bennetzen, J.L. & Hall, B.D./Codon Selection in Yeast/The Journal of Biological Chemistry/(1982), 257(6), 3026-3031.
Tam, L-T. et al/The Hemoglobins of the Bullfrog Rana catesbeiana, The Structure of the .beta. Chain of Component C and the Role of the .alpha. Chain in the Formation of Intermolecular Disulfide Bonds/The J. of Biol. Chem./(1986), 261(18), 8290-8294.
Schoner, B.E. et al/Translation of a Synthetic Two-Cistron mRNA in Escherichia coli/PNAS/(1986), 83, 8506-8510.
Riggs, A./Hemoglobin Polymerization in Mice/Science/(1965), 147, 621-623.
Takenaka, O. et al/Hemoglobin Izu(Macaca): .beta.83 (EF 7) GLY.fwdarw.CYS. A New Hemoglobin Variant Found in the Japanese Monkey (Macaca fuscata)/Biochim. et Biophys. ACTA/(1977), 492, 433-444.
Bonaventura, J. & Riggs, A./Polymerization of Hemoglobins of Mouse and Man: Structural Basis/Science/(1967), 153, 800-802. Variant with Anomalous Properties/Hemoglobin/(1987), 11(5), 435-452.
Tondo, C.V./Osmometric Study of the Subunit Dissociation of Hemoglobin Bras. Ci.,/(1987), 59(3), 243-251.
Tondo, C.V. et al/Functional Properties of Hemoglobin Porto Alegre (.alpha..sub.2.sup.A .beta..sub.2.sup.9 SER.fwdarw.CYS) and the Reactivity of its Extra Cysteinyl Residue/Biochim. et Biophys. ACTA/(1974), 342, 15-20.
Greer, J. & Perutz, M.F./Three Dimensional Structure of Haemoglobin Rainier/Nature New Biology/(1971), 230, 261-264.
Tam, S-C. & Wong, J.T-F./Impairment of Renal Function by Stroma-Free Hemoglobin in Rats/J. Lab. Clin. Med./(1988), 111(2), 189-193.
Lee, R. et al/Ultrapure, Stroma-Free, Polymerized Bovine Hemoglobin Solution: Evaluation of Renal Toxicity/J. of Surgical Res./(1989), 47, 407-411.
Bunn, H.F. & Jandl, J.H./The Renal Handling of Hemoglobin II. Catabolism/J. Exp. Med./(1969), 129, 925-936.
Bunn, H.F. et al/The Renal Handling of Hemoglobin I. Glomerular Filtration/J. Exp. Med./(1969), 129, 909-923.
Holden, S.A. et al./Effect of a PFOB Emulsion (Oxygent) and Carbogen Breathing on the Tumor Cell Survival of the FSaIIC Fibrosarcoma After Treatment with Antitumor Alkylating Agents/Biomat. Art. Cells./(1991), 19(2), 399.
Herman, T.S. & Teicher, B.A./Enhancement of Radiation Therapy by an Experimental Concentra

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