DNA encoding variants of tissue plasminogen activators and expre

Details DNA encoding variants of tissue plasminogen activators and expre DNA encoding variants of tissue plasminogen activators and expre

1993-03-22

1994-09-13

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 232, 435212, 435226, 4353201, 4352542, C12N 964, C12N 1500, C12N 1558

Patent

active

053468244

ABSTRACT:
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.

REFERENCES:
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 5041376 (1991-08-01), Gething et al.
Pharmacia Fine Chemicals Catalogue 84, pp. 1 and 6.
Kaufman et al., Gene Amplification, 245-250, Cold Spring Harbor Laboratory (1982).
Ny et al., DNA, 7(10):671-677 (1988).
Rickles et al., J. Biol. Chem., 263(3):1563-1569 (1988).
Gardell et al., J. Biol. Chem., 264(30):17947-17952 (1989).
Machamer & Rose, J. Biol. Chem., 263(12):5948-5954 (1988).
Machamer & Rose, J. Biol. Chem., 263(12):5955-5960 (1988).
Browne et al., J. Biol. Chem., 263(4):1599-1602 (1988).
Harris, Protein Engineering, 1(6):449-458 (1987).
Berman & Lasky, Trends in Biotechn., 3(2):51-53 (1985).

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