DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6)

Details DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6) DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6)

1994-05-13

1998-12-08

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4351723, 4352523, 536 235, 536 231, C12N 510, C12N 1512, C12N 121

Patent

active

058467637

ABSTRACT:
TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.

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