DNA encoding tissue factor mutants useful for the treatment of m

Details DNA encoding tissue factor mutants useful for the treatment of m DNA encoding tissue factor mutants useful for the treatment of m

1994-05-20

1996-12-31

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530381, 536 235, 536 234, 4351723, 4352402, 4352523, C07K 14745, C12N 113, C12N 1512, C12N 1563

Patent

active

055893635

ABSTRACT:
DNA enclosing a tissue factor protein mutant capable of neutralizing the ability of endogenous tissue factor to induce coagulation is provided. A representative tissue factor mutant designated K165A, K166A TF is useful in a method for inhibiting thrombin-induced platelet aggregation in a mammal, either separately or in combination with a thrombolytic agent, an anticoagulant, or a GPII.sub.blll.sub.a inhibitor.

REFERENCES:
patent: 4966852 (1990-10-01), Wun et al.
patent: 5110730 (1992-05-01), Edgington
patent: 5374617 (1994-12-01), Morrissey
Bach, "Initiation of Coagulation by Tissue Factor", CRC Critical Reviews in Biochemistry, 23(4):339-368 (1988).
Fisher et al., "Cloning and Expression of Human Tissue Factor cDNA", Thrombosis Research, 48:89-99 (1987).
Harrison's Principles of Internal Medicine, 11th Ed., p. 1478.
Krangel et al., "Characterization of a B Lymphoblastoid Cell Line Mutant that Secretes HLA-A2", J. Immunol., 132(6):2984-2991 (1984).
Mason et al., "Activin B: Precursor Sequences, Genomic Structure and in Vitro Activities", Molecular Endocrinology, 3(9):1352-1358 (1989).
O'Brien et al., "Factor VIII-Bypassing Activity of Bovine Tissue Factor Using the Canine Hemophilic Model", J. Clin. Invest., 82:206-211 (1988).
Paborsky et al., "Purification of Recombinant Human Tissue Factor", Biochemistry, 28(20):8072-8077 (1989).
Roy et al., "Self-association of Tissue Factor as Revealed by Chemical Cross-linking", J. Biol. Chem., 266(8):4665-4668 (1991).
Sakai et al., "Binding of Human Factors VII and VIIa to a Human Bladder Carcinoma Cell Line (J82)", J. Biol. Chem., 264(17):9980-9988 (1989).
Spicer et al., "Isolation of cDNA clones coding for human tissue factor: Primary structure of the protein and cDNA", Proc. Natl. Acad. Sci. USA, 84:5148-5152 (1987).
Taylor et al., "Lethal E. coli Septic Shock is Prevented by Blocking Tissue Factor With Monoclonal Antibody", Circulatory Shock, 33:127-134 (1991).

Affiliated with

Also associated with

Rating

DNA encoding tissue factor mutants useful for the treatment of m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding tissue factor mutants useful for the treatment of m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding tissue factor mutants useful for the treatment of m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1141431