Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-06-01
1995-06-06
Lacey, David L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4241911, 4242651, 435 693, 4353201, 4351723, 5303886, 536 231, 536 243, C07K 1528, C12N 1530, C12P 2108, A61K 39002
Patent
active
054222630
ABSTRACT:
Disclosed are DNA sequences which encode an amino acid sequence homologous to a segment of Trichinella spiralis 53 kilodalton excretory-secretory antigen, recombinant polynucleotide molecules containing the sequences, and transfer and replication of the sequences in a transformed host to produce antigens useful as immunodiagnostic reagents or vaccines specific for T. spiralis.
REFERENCES:
patent: 4670384 (1987-06-01), Gamble et al.
Sugane et al, J Helminthology 61(1), 1-8, (1987) Translation products of mRNA from infective larvae.
D. S. Zarlenga and H. R. Gamble, "Identification of cDNA Clones Expressing Immunodiagnostic Antigens from Trichinella spiralis," (Abstract), Federation Proceedings 46: 2038 (1987).
H. R. Gamble and C. E. Graham, "Monoclonal Antibody-Purified Antigen for the Immunodiagnosis of Trichinosis," American Journal of Veterinary Research 45:67-74 (1984).
H. R. Gamble, "Trichinella spiralis: Immunization of Mice Using Monoclonal Antibody Affinity-Isolated Antigens," Experimental Parasitology 59:398-400 (1985).
H. R. Gamble, W. R. Anderson, C. E. Graham and K. D. Murrell, "Diagnosis of Swine Trichinosis by Enzyme-Linked Immunosorbent Assay (ELISA) Using an Excretory-Secretory Antigen," Veterinary Parasitology 13:349-361 (1983).
G. L. Seawright et al., American Journal of Tropical Med. Hyg. 32:1275-1284 (1983).
D. S. Silberstein, "Studies on Antigens of Trichinella Spiralis," (Abstract), Dissertation Abstracts International 45:624-B (1984).
D. S. Silberstein and D. D. Despommier, "Antigens from Trichinella spiralis that Induce a Protective Response in the Mouse," The Journal of Immunology 132:898-904 (1984).
D. S. Zarlenga and H. R. Gamble, "Simultaneous Isolation of Preparative Amounts of RNA and DNA from Trichinella spiralis by Cesium Trifluoroacetate Isopycnic Centrifugation," Analytical Biochemistry 162:569-574 (1987).
G. R. Klassen, J. P. Thiessen and T. A. Dick, "Strain-Specific 1.7 Kilobase Repetitive Deoxyribonucleic Acid Sequence Family in Trichinella spiralis," Molecular and Biochemical Parasitology 21:227-233 (1986).
J. B. Dame, D. D. Murrell, D. E. Worley and G. A. Schad, "Trichinella spiralis: Genetic Evidence for Synanthropic Subspecies in Sylvatic Hosts," Experimental Parasitology 64:195-203 (1987).
Gamble H. Ray
Zarlenga, Jr. Dante S.
Connor Margaret A.
Fado John D.
Lacey David L.
Nisbet T. Michael
Silverstein M. Howard
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