DNA encoding the Trichinella spirals 53kD excretory/secretory an

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4241911, 4242651, 435 693, 4353201, 4351723, 5303886, 536 231, 536 243, C07K 1528, C12N 1530, C12P 2108, A61K 39002

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active

054222630

ABSTRACT:
Disclosed are DNA sequences which encode an amino acid sequence homologous to a segment of Trichinella spiralis 53 kilodalton excretory-secretory antigen, recombinant polynucleotide molecules containing the sequences, and transfer and replication of the sequences in a transformed host to produce antigens useful as immunodiagnostic reagents or vaccines specific for T. spiralis.

REFERENCES:
patent: 4670384 (1987-06-01), Gamble et al.
Sugane et al, J Helminthology 61(1), 1-8, (1987) Translation products of mRNA from infective larvae.
D. S. Zarlenga and H. R. Gamble, "Identification of cDNA Clones Expressing Immunodiagnostic Antigens from Trichinella spiralis," (Abstract), Federation Proceedings 46: 2038 (1987).
H. R. Gamble and C. E. Graham, "Monoclonal Antibody-Purified Antigen for the Immunodiagnosis of Trichinosis," American Journal of Veterinary Research 45:67-74 (1984).
H. R. Gamble, "Trichinella spiralis: Immunization of Mice Using Monoclonal Antibody Affinity-Isolated Antigens," Experimental Parasitology 59:398-400 (1985).
H. R. Gamble, W. R. Anderson, C. E. Graham and K. D. Murrell, "Diagnosis of Swine Trichinosis by Enzyme-Linked Immunosorbent Assay (ELISA) Using an Excretory-Secretory Antigen," Veterinary Parasitology 13:349-361 (1983).
G. L. Seawright et al., American Journal of Tropical Med. Hyg. 32:1275-1284 (1983).
D. S. Silberstein, "Studies on Antigens of Trichinella Spiralis," (Abstract), Dissertation Abstracts International 45:624-B (1984).
D. S. Silberstein and D. D. Despommier, "Antigens from Trichinella spiralis that Induce a Protective Response in the Mouse," The Journal of Immunology 132:898-904 (1984).
D. S. Zarlenga and H. R. Gamble, "Simultaneous Isolation of Preparative Amounts of RNA and DNA from Trichinella spiralis by Cesium Trifluoroacetate Isopycnic Centrifugation," Analytical Biochemistry 162:569-574 (1987).
G. R. Klassen, J. P. Thiessen and T. A. Dick, "Strain-Specific 1.7 Kilobase Repetitive Deoxyribonucleic Acid Sequence Family in Trichinella spiralis," Molecular and Biochemical Parasitology 21:227-233 (1986).
J. B. Dame, D. D. Murrell, D. E. Worley and G. A. Schad, "Trichinella spiralis: Genetic Evidence for Synanthropic Subspecies in Sylvatic Hosts," Experimental Parasitology 64:195-203 (1987).

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