DNA encoding the T cell surface protein T4 and use of fragments

Details DNA encoding the T cell surface protein T4 and use of fragments DNA encoding the T cell surface protein T4 and use of fragments

1995-06-05

1999-02-16

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 536 2431, C12Q 168, C07H 2104

Patent

active

058719130

ABSTRACT:
A single-stranded nucleic acid molecule which encodes the amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4 cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.

REFERENCES:
Littman et al., Cell vol. 40 pp. 237-246 1985.
Murre et al., Molecular and Cellular Biology 6(4) pp. 1315-1319.
Maddon et al; Cell 42 93-104 (1985).
Littman et al; ICSU Short Reports 2 233-234 (1985) Cambridge Univ Press, N.Y. N.Y.
Dalgeish et al; Nature 312 (1984) pp. 763-767.
Klatzmann et al; Nature 312 (1984) pp. 767-768.
Terhorst et al; Science 209, 520-521 (1980).

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