DNA encoding the novel mammalian protein, Ire1p

Details DNA encoding the novel mammalian protein, Ire1p DNA encoding the novel mammalian protein, Ire1p

2004-07-14

2008-10-21

Hayes, Robert C (Department: 1649)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07439061

ABSTRACT:
A novel polynucleotide encoding a mammalian bifunctional protein kinase\endoribonuclease referred to herein as hIre1p, is provided. hIre1p is expressed in the endoplasmic reticulum (ER) and upregulates the transcription of genes encoding ER protein chaperones, such as, but not limited to, glucose-related proteins (GRP's). Therapeutic, diagnostic and research methods employing the polynucleotide and protein are also provided.

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