DNA encoding the mouse and human PH30 beta chain protein

Details DNA encoding the mouse and human PH30 beta chain protein DNA encoding the mouse and human PH30 beta chain protein

1994-06-20

1997-12-02

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 43525411, 4352551, 4353201, 4352542, 536235, C12N 1512, C12N 1563

Patent

active

056934963

ABSTRACT:
The instant invention is drawn to a DNA encoding a sperm surface protein in substantially pure form selected from a human PH30 beta chain protein and a mouse PH30 beta chain proteins. Such proteins are useful as contraceptive vaccines in humans and mice respectively, and for identifying small molecules that will disrupt sperm-egg interaction and fertilization,

REFERENCES:
patent: 4879213 (1989-11-01), Fox et al.
Journal of Cell Biol., Primakoff et al., Identification & Purification of a Sperm Surface Protein vol. 104, Jan. 1987, pp. 141-149.
Nature, Blobel et al., A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion, vol. 356, 19 Mar. 1992.
Journal of Cell. Biol., Blobel et al., Proteolytic Processing of a Protein involved in Sperm-Egg Fusion, vol. 111, Jul. 1990, pp. 69-78.
Proc. Natl. Acad. Sci., Myles et al., Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion, USA, vol. 91, pp. 4195-4198.
Bowie et al. Science 247:1306-1310 Mar. 1990.
Kumar et al PNAS 87:1337-1341 1990.
Smith et al Mol. Cell Biology 3(12):2156-2165 1983.
Pennock et al. Mol. Cell Biology 4(3):399-406 Mar. 1984.

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