Chemistry: molecular biology and microbiology – Vector – per se
Patent
1986-02-24
1989-06-13
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Vector, per se
435 68, 435 70, 4351723, 4352402, 4353171, 43525233, 435235, 536 27, 935 11, 935 29, 935 32, 935 47, 935 48, C12N 1500, C12P 2100, C12P 2102, C07H 1512
Patent
active
048392936
ABSTRACT:
DNA which encodes the polypeptide streptavidin has been isolated as a fragment 2 kb in length derived from a restriction endonuclease digestion of the chromosomal DNA of Streptomyces avidinii. The nucleic acid sequence of the gene and the amino acid sequence of the polypeptide have been determined. A fused gene has been prepared which comprises the streptavidin gene fused to a gene encoding the human LDL receptor. Expression of the gene fusion results in a fused streptavidin-human LDL receptor polypeptide. Methods are provided for using the fused gene to produce labeled, chemically modified proteins in vivo and to isolate a protein knowing only the nucleotide sequence of the gene encoding the protein.
REFERENCES:
patent: 4356270 (1982-10-01), Itakura
patent: 4438032 (1984-03-01), Golde et al.
patent: 4478914 (1984-10-01), Giese
patent: 4617261 (1986-10-01), Sheldon et al.
Argarana Carlos
Axel Richard
Cantor Charles R.
Mays Thomas D.
Santalone John J.
The Trustees of Columbia University in the City of New York
Weimar Elizabeth C.
White John P.
LandOfFree
DNA encoding streptavidin, streptavidin produced therefrom, fuse does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding streptavidin, streptavidin produced therefrom, fuse, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding streptavidin, streptavidin produced therefrom, fuse will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1277337