DNA encoding Slo2 and Slo4, potassium channel

Details DNA encoding Slo2 and Slo4, potassium channel DNA encoding Slo2 and Slo4, potassium channel

2006-05-09

2006-05-09

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Vector, per se

C435S325000, C536S023500

Reexamination Certificate

active

07041494

ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.

REFERENCES:
patent: 2002/0048787 (2002-04-01), Wei et al.
patent: 2003/0143675 (2003-07-01), Curtis et al.
patent: WO 99/20754 (1999-04-01), None
patent: WO 01/90366 (2001-11-01), None
Joiner et al., “Formation of intermediate-conductance calcium activated potassium channels by interaction of Slack and Slo subunits,” Nature Neuroscience, Oct. 1998, pp. 462-469, vol. 1(6).

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