Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
1997-09-23
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 435325, 435419, 536 236, C12P 2106, C12N 506, C12N 1503, C07H 2104
Patent
active
056703392
ABSTRACT:
Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
REFERENCES:
patent: 3998798 (1976-12-01), Cagan et al.
patent: 5487983 (1996-01-01), Kim et al.
De Vos et al., Three-dimensional structure of thaumatin I, an intensely sweet protein; Proc. Natl. Acad. Sci. USA (1985) 82:1406-1409.
Ogata et al., Crystal structure of the intensely sweet protein monellin; Nature (1987) 328:739-742.
Morris et al., Characterization of monellin, a protein that tastes sweet; J. Biol. Chem. (1973) 248:534-539.
Cagan R.H., Chemostimulatory protein: A new type of taste stimulus; Science (1973) 181:32-25.
Bohak et al., The structure of monellin and its relation to the sweetness of the protein; Biochim. Biophys. Acta. (1976) 427:153-170.
Hudson et al., Mass spectrometric sequencing of proteins. The structure of subunit I of monellin; Biochem. Biophys. Res. Comm. (1976) 71:212-220.
Van der Wel et al., Characterization of the sweet-tasting protein from dioscoreophyllum cumminsi (Stapf) diels; FEBS Lett (1973) 29:181-183.
Frank et al., The complete amino acid sequences of both subunits of the sweet protein monellin; Z. Physiol. Chem. (1976) 357:585-592.
Morris et al., Purification of monellin, the sweet principle of dioscoreophyllum cumminsii; Biochim. Biophys. Acta. (1972 261:114-122.
Protein Stability & Stabilization Through Protein Engineering, Nosoh et al., 1991, Ellis Horwood, Pub; N.Y. p. 62.
Cho Joong Myung
Kim Sung-Hou
Arthur Lisa B.
Lucky Biotech Corp.
The Regents of the University of California
LandOfFree
DNA encoding single chain monellin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding single chain monellin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding single chain monellin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1938294