DNA encoding serS polypeptides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 4353201, 435325, 536 237, C12P 2106, C12N 120, C12N 1500, C07H 2104

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active

060080213

ABSTRACT:
The invention provides serS polypeptides and DNA (RNA) encoding serS polypeptide and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing serS polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5476929 (1995-12-01), Briles et al.
Lazar et al (Molecullar & Cellular Biology vol. 8 No. 3, Mar. 1988 pp. 1247-1252).
Burgess et al (J. of Cell Biology vol. III, Nov. 1990 pp. 2129-2138).
Salgaller et al (Cancer. Immunol. Immunother. vol. 39, 1990 pp. 105-116).
Lindler et al (J. of Bacteriology vol. 169 No. 7, Jul. 1987 pp. 3199-3208).
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) p. 1681-1690 (1966).
J. Hughes et al., "How does Pseudomonoas Fluorescens, the Producing Organism of the Antibotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 322-324 (1980).

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