Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1989-01-18
1991-01-15
Spiegel, Jack
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4351721, 4352402, 435272, 435320, 436501, 536 26, 536 27, 536 28, 935 18, 935 23, 935 32, 935 33, 935 34, 935 56, 935 60, 935 70, 935 77, 935 78, 935 80, C12Q 168, C12M 1500, G01N 33566, C07H 1512
Patent
active
049853520
ABSTRACT:
The invention relates to DNA encoding a functional serotonin 5HT1c receptor, e.g., cDNA, and to the isolated, functional serotonin 5HT1c receptor encoded by such DNA. The invention also relates to mammalian cells expressing the cDNA encoding the 5HT1c receptor and to a DNA probe useful for detecting nucleic acid encoding the serotonin 5HT1c receptor. This invention provides methods for determining binding to the serotonin 5HT1c receptor, methods of detecting the expression, and the presence of the serotonin 5HT1c receptor on the surface of a cell and to a method of screening drugs to identify drugs which specifically interact with, and bind to the serotonin 5HT1c receptor on the surface of a cell.
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Axel Richard
Jessell Thomas M.
Julius David J.
Spiegel Jack
The Trustees of Columbia University in the City of New York
White John P.
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