Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-05-09
2006-05-09
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C536S023500
Reexamination Certificate
active
07041496
ABSTRACT:
The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
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Blanar Michael A.
Dworetzky Steven
Gribkoff Valentin K.
Levesque Paul C.
Little Wayne A.
Bergen Briana
Bristol-Myers Squibb
Lamerdin John A.
Pak Michael
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