DNA encoding rodent KCNQ2 potassium channel

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C435S325000, C536S023500

Reexamination Certificate

active

07041496

ABSTRACT:
The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

REFERENCES:
patent: 9191882 (1997-07-01), None
patent: WO9921875 (1999-05-01), None
D82346Homo sapensmRNA for HNSPC, complete cds, Yokoyama et al., Sequence submitted Dec. 21, 1995; Released to public: Feb. 14, 1997; National Center for Biotechnology Information (NCBI)21.
Barhanin et al. (1996) Nature 384:78-80.
Sanguinetti et al. (1996) Nature 384:80-83.
Yang et al. (1997) Proc. Natl. Acad. Sci. 94:4017-4022.
Wang et al. (1996) Nature Genetics 12:17-23.
Wei et al. (1996) Neuropharmacology 35:805-829.
Halliwell (1990) Potassium Channels-Structure, Classification, Function and Therapeutic Potential (N.S. Cook, ed.) 384:381.
Pongs (1992) Physiol Rev. 72:S69-S88.
Biervert et al. (1998) Science 279:403-406.
Charlier et al. (1998) Nature Genetics 18:53-55.
Singh et al. (1998) Nature Genetics 18:25-29.
Jan, L.Y. and Jan, Y.N. (1992) Ann. Rev. Physiol. 54:537-555.
Catterall (1995) Ann. Rev. Biochem. 64:493-531.
U.S. Appl. No. 10/131,685, filed Apr. 24, 2002.
Yokoyama et al. (1996) DNA Research 3:311-320.
NCBI Entrez Accession No. P51787 (gi:6166005), Chouabe, et al., Jun. 15, 2004.
Database Uniprot, Oct. 1, 1966, Chouabe, et al., XP002290070.

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