DNA encoding retinotic acid receptor epsilon

Details DNA encoding retinotic acid receptor epsilon DNA encoding retinotic acid receptor epsilon

1995-06-06

1999-02-09

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4352523, 536 235, 530350, 730180, 535 1, 535 3, 535 10, 535 23, 535 35, 535 66, C12N 1512, C12P 2100, C07K 14705

Patent

active

058692843

ABSTRACT:
Disclosed is a retinoic acid receptor epsilon (RAR.epsilon.) polynucleotide and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, tissue regeneration and stimulation of the immune and hematopoietic system. Also disclosed are methods of identifying ligands which stimulate the RAR.epsilon.. Also disclosed are diagnostic methods for detecting a mutation in the RAR.epsilon. receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

REFERENCES:
patent: 5260432 (1993-11-01), Takaku et al.
patent: 5262300 (1993-11-01), Evans et al.
Lohnea, D., et al., Cell, 73:643-658 (1993).
Koelle, M. R., et al., Cell, 67:59-77 (1991).
Lazoga, D., et al., Journal of Cellular Physiology, 157:90-96 (1993).
Nagpal, S., et al., The EMBO Journal, 12(6):2349-2360 (1993).

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