Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-10-31
1998-07-28
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 536 235, 530350, C12N 121, C12N 1563, C07H 2104, C07K 14775
Patent
active
057862060
ABSTRACT:
Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
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Curtiss Linda K.
Koduri Kanaka Raju
Smith Richard S.
Witztum Joseph L.
Young Stephen G.
Lau Kawai
The Scripps Research Institute
Wax Robert A.
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