DNA encoding recombinant human lymphotoxin

Details DNA encoding recombinant human lymphotoxin DNA encoding recombinant human lymphotoxin

1989-10-03

1992-12-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 530351, C07H 2104, C12N 1519

Patent

active

051752689

ABSTRACT:
Lymphotoxin (LT) mutein (genetically-altered LT) is disclosed that has the following amino acid sequence, or a portion of an active portion of said protein, where 10 to 21 amino acids of LT being deleted from N-terminus and which has Pro or Phe at the N-terminus: ##STR1## Wherein R.sub.1 is Pro or Phe, R.sub.2 is a peptide chain represented by the following sequence:

REFERENCES:
patent: 4677063 (1987-06-01), Mark et al.
patent: 4677064 (1987-06-01), Mark et al.
patent: 4782139 (1988-11-01), DiMarchi et al.
Kobayashi et al., Journal of Biochemistry, vol. 100, No. 3, 727-733 (Sep. 1986).
Aggarwall et al., J. Biol. Chem., 259: 686 (1984).
Gray et al., Nature 312: 721 (1984).
Pennica et al., Nature 312: 724, (1984).
Aggarwal et al., J. Biol. Chem. 260: 2334 (1985).

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