DNA encoding rabbit TNE, vector having said DNA inserted therein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4351723, 4353201, 4352523, 43525233, 435 91, 435255, 4352401, 4352402, 4352404, 536 27, 935 73, 935 62, 935 60, 935 27, 935 11, 935 21, C12P 2100, C12N 1500, C12N 120, C07H 1012

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050432710

ABSTRACT:
A novel cloned DNA encoding a rabbit Tumor Necrosis Factor (TNF) or a principal portion thereof, a vector having said DNA inserted thereinto, a host transformed with said vector, a novel polypeptide having or containing the rabbit TNF or a principal portion thereof, and a process for producing said polypeptide comprising cultivating said transformed host.

REFERENCES:
patent: 4529594 (1985-07-01), Hayashi et al.
patent: 4879226 (1989-11-01), Wallace et al.
Ruff et al., J. Immunology, vol. 125(4), Oct. 1980, pp. 1671-1677, "Purification and Physio-Chemical Characterization of Rabbit Tumor Necrosis Factor".
Matthews et al., Br. J. Cancer, vol. 42, pp. 416-422, 1980, "Tumor Necrosis Factor from the Rabbit, IV, Purification and Chemical Characterization".
Matthews et al., Br. J. Cancer, vol. 38, 1978, pp. 302-304, "Tumor Necrosis Factor from the Rabbit, I, Mode of Action, Specificity and Physiochemical Properties".
Matthews, Br. J. Cancer, vol. 44, pp. 418-424, 1981, "Tumor-Necrosis Factor from the Rabbit, V, Synthesis In Vitro by Mononuclear Phagocytes from Various Tissues of Normal and BCG-Injected Rabbits".

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