Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-10-10
2000-07-25
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 2104
Patent
active
060938064
ABSTRACT:
The present invention is directed to isolated nucleic acid molecules encoding proteins of Kaposi's sarcoma associated herpesvirus, including an antigenic receptor protein, a G protein coupled receptor, and a cyclin protein. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of the KSHV proteins in host cells. DNA oligomers and antibodies specific for the KSHV proteins are provided, each of which can be used to detect the KSHV proteins in a sample. Isolated KSHV proteins are also provided.
REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Uhlmann et al., Antisense oligonucleotides: a new therapeutic principle, Chemical Reviews, vol. 90(4), pp. 543-584, Jun. 1990.
Gewirtz et al., Facility oligonucleotide delivery: helping antisense deliver on its promise, Proc. Natl. Acad. Sci., vol. 93, pp. 3161-3163, Apr. 1996.
Ngo et al., Computational complexity, protein structure prediction, and the Levinthal paradox, The Protein Folding Problem and Tertiary Structure Prediction, pp. 433-440, 1994.
Chang et al., Identification of herpes-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science, vol. 266 (5192), pp. 1865-1869, Dec. 12, 1994.
Baer et al., "DNA Sequence and Expression of the B95-8 Epstein-Barr Virus Genome," Nature 310:207-211 (1984).
Cameron et al., "The 160,000-M.sub.r Virion Protein Encoded at the Right End of the Herpesvirus Saimiri Genome Is Homologous to the 140,000-M .sub.r Membrane Antigen Encoded the Left End of the Epstein-Barr Virus Genome," Journal of Virology, 61:2063-2070 (1987).
Albrecht et al., "Primary Structure of the Herpesvirus Saimiri Genome," Journal of Virology , 66:5047-5058 (1992).
Nicholas et al., "Herpesvirus Samiri Encodes Homologues of G Protein-Coupled Receptors and Cyclins," Nature, 355:362-365 (1992).
Strader et al., "Structure and Function of G Protein-Coupled Receptors," Annu. Rev. Biochem., 63:101-132 (1994).
Ambroziak et al., "Herpes-Like Sequences in HIV-Infected and Uninfected Kaposi's Sarcoma Patients," Science, 268:582-583 (1995).
Arvanitakis et al., "Latent Membrane Protein-1 Induces Cyclin D2 Expression, pRb Hyperhosphorylation, and Loss of TGF-.beta.1-Mediated Growth Inhibition in EBV-Positive B Cells," The Journal of Immunology, pp. 1047-1056 (1995).
Boshoff et al., "Kaposi's-Sarcoma-Associated Herpesvirus In HIV-Negative Kaposi's Sarcoma," The Lancet 345:1043-1044 (1995).
Cesarman et al., "Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences in Aids-Related Body-Cavity-Based Lymphomas," The New England Journal of Medicine, 332:1186-1191 (1995).
Cesarman et al., In Vitro Establishment and Characterization of Two Acquired Immunodeficiency Syndrome-Related Lymphoma Cell Lines (BC-1 and BC-2) Containing Kaposi's Sarcoma-Associated Herpesvirus-Like (KSHV) DNA Sequences, Blood, 86:2708-271 (1995).
Dupin et al., New England Journal of Medicine, p. 798 (1995).
Dupin et al., "Herpesvirus-Like DNA Sequences In Patients With Mediterranean Kaposi's Sarcoma," The Lancet, 345:761-762 (1995).
Karcher et al., "Herpes-Like DNA Sequences, Aids-Related Tumors, and Castleman's Disease," The New England Journal of Medicine, 333:797-798 (1995).
Moore et al., "Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients With and Those Without HIV Infection," The New England Journal of Medicine, 332:181-191 (1995).
Noel, "Kaposi's Sarcoma and KSHV," 346:1359-1360 (1995).
Schalling et al, "A Role For A New Herpes Virus (KSHV) In Different Forms of Kaposi's Sarcoma," Nature Medicine, 1:707-708 (1995).
Shingadia et al., The Lancet, 346:1359-1361 (1995).
Soulier et al., "Kaposi's Sarcoma-Associates Herpesvirus-Like DNA Sequences in Multicentric Castleman's Disease," Blood, 86:1276-1280 (1995).
Whitby et al., "Detection of Kaposi Sarcoma-Associated Herpesvirus in Peripheral Blood of HIV-Infected Individuals and Progression to Kaposi's Sarcoma," The Lancet, 346:799-802 (1995).
Renne et al., Lytic Growth of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) in Culture, Nature Medicine, 2:342-346 (1996).
Gessain et al., "Kaposi Sarcoma-Associated Herpes-Like Virus (Human Herpesvirus Type 8) DNA Sequences in Multicentric Castleman's Disease: Is There Any Relevant Association In Non-Human Immunodeficiency Virus-Infected Patients?," Blood, pp. 414-418 (1996).
Cesarman Ethel
Knowles Daniel M.
Cornell Research Foundation Inc.
Elliott George C.
Wang Andrew
LandOfFree
DNA encoding proteins of Kaposi's sarcoma associated herpesvirus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding proteins of Kaposi's sarcoma associated herpesvirus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding proteins of Kaposi's sarcoma associated herpesvirus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1337407