Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-04-08
1996-09-03
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4352402, 4353201, C07H 2102, C07H 2104, C12N 1570, C12N 510
Patent
active
055525369
ABSTRACT:
A complementary DNA (cDNA) encoding full length form of ICE.sub.rel -III is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICE.sub.rel -III. The cDNA and the recombinant ICE.sub.rel -III protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICE.sub.rel -III protein may be used to identify compounds that affect ICE.sub.rel -III function, inflammation and cell apoptosis. ICE.sub.rel -III function, inflammation and cell apoptosis may also be modulated by ICE.sub.rel -III antisense or gene therapy.
REFERENCES:
patent: 5416013 (1995-05-01), Black et al.
Barinaga, M. "Cell Suicide: by ICE, Not Fire", Science, vol. 263, Feb. 11, 1994 pp. 754-756.
Cerretti, D. P. et al. "Molecular Cloning of the Interleukin-1 beta converting Enzyme", Science, vol. 256, 3 Apr. 1992 pp. 97-100.
Gagliardini, V. et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene", Science, vol. 263, 11 Feb. 1994, pp. 826-828.
Miura, M. et al., "Induction of Apoptosis in Fibroblasts by IL-1 Beta-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3", Cell, vol. 75, Nov. 19, 1993, pp. 653-660.
Thornberry, N. A. et al. "A Novel Heterodimeric Cysteine Protease is Required for Interleukin-1 Beta Processing in Monocyles", Nature, vol. 356, Apr. 30, 1992, pp. 768-774.
Yuan, J. et al., "The C. elegans Cell Death Gene ced-3 Encodes of Protein Similar to Mammalian Interleukin 1 Beta-Converting Enzyme", Cell, vol. 75, Nov. 19, 1993, pp. 641-652.
New England Biolabs Catalog (1993-1994), p. 92.
Munday et al, (1995), "Molecular cloning and pro-apoptotic activity if ICE.sub.rel II and ICE.sub.rel III, members of the ICE/CED-3 family of cysteine proteases", J. Biol. Chem. 270(26): 15870-15876.
Kamens et al, (1995), "Identification and characterization of ICH-2, a novel member of the interleukin-1B-converting enzyme family of cysteine proteases", J. Biol. Chem. 270(25): 15250-15256.
Alnemri et al, (1995), "Cloning and expression of four novel isoforms of human interleukin-1B converting enzyme with different apoptoic activities", J. Biol. Chem. 270(9):4312-4317.
Fancheu et al, (1995), "A novel human protease similar to the interleukin-1B converting enzyme induces apoptosis in transfected cells", EMBO J. 14(9): 1914-1922.
Ali Ambereen
Munday Neil A.
Nicholson Donald W.
Vaillancourt John P.
Carty Christine E.
Fredman Jeffrey
Merck Frosst Canada Inc.
Tribble Jack L.
Zitomer Stephanie W.
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