DNA encoding polypeptides with activity against gram-positive an

Details DNA encoding polypeptides with activity against gram-positive an DNA encoding polypeptides with activity against gram-positive an

1993-01-28

1994-09-06

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 530370, 530350, 536 234, C07K 700, C12N 1562

Patent

active

053447654

ABSTRACT:
The invention relates to cecropin-like polypeptides with a variety of C-terminus modifications. Conversion of the terminal carboxy group to a homoserine extended neutral, negatively charged or positively charged form results in the polypeptides of the invention that have significant bactericidal effects against both Gram-positive and Gram-negative bacteria.

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