DNA encoding platelet derived endothelial cell growth factor (PD

Details DNA encoding platelet derived endothelial cell growth factor (PD DNA encoding platelet derived endothelial cell growth factor (PD

1991-08-02

1993-07-13

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 2351, 536 235, 4352523, 43525233, 4353201, 530350, 530399, C07H 2104, C12N 1500, C12N 1518, C12N 1512

Patent

active

052273024

ABSTRACT:
Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa endothelial cell mitogen that has been purified to homogeneity from human platelets. It does not bind to heparin and does not stimulate the proliferation of fibroblasts, in contrast to other endothelial mitogens of the fibroblast growth factor (FGF) family. PD-ECGF appears to be the only endothelial cell growth factor in human platelets and recent data indicate that it has angiogenic activity in vitro, i.e., the ability to stimulate the formation of new blood vessels and chemotactic activity, in vitro. The present invention provides a homogeneous PD-ECGF in substantially greater yields than available in the past, the primary structure of PD-ECGF, antibodies against PD-ECGF, clones of its cDNA, and variants thereof. The invention also provides a therapeutic preparation of PD-ECGF.

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