Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-05-02
1996-12-03
Hendricks, Keith D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, C12N 1512
Patent
active
055809685
ABSTRACT:
The invention provides methods for detecting elevated levels of phospholipase A.sub.2 activating protein in persons suspected of having rheumatoid arthritis to thereby indicate the presence of rheumatoid arthritis in the person comprising the steps of providing a sample of body fluid or tissue from said person; contacting the sample with an antibody specific for phospholipase A.sub.2 activating protein such that the antibody binds with phospholipase A.sub.2 activating protein in the sample; detecting the antibody thereby indicating the presence of phospholipase A.sub.2 activating protein, whereby elevated levels of phospholipase A.sub.2 activating protein in the sample as compared with levels found in persons not having rheumatoid arthritis indicates the presence of rheumatoid arthritis in the person. Kits and reagents for detecting rheumatoid arthritis are also provided.
REFERENCES:
Young et al., PNAS, vol. 80, Mar. 1983, pp. 1194-1198.
Bomalaski et al., "Rheumatoid Arthritis Synovial Fluid Phospholipase A.sub.2 Activating Protein (PLAP) Stimulates Human Neutrophil Degranulation and Superoxide Ion Production", Agents & Actions vol. 27, Nos. 3/4: 425-427 (1989).
Clark et al., "Tumour Necrosis Factor (Cachectin) Induces Phospholipase A.sub.2 Activating and Synthesis of a Phospholipase A.sub.2 -Activating Protein in Endothelial Cells", Adv. Exp. Med. Biol. vol. 275: 125-144 (1990).
Clark et al., "Identification and Isolation of a Mammalian Protein Which Is Antigenically and Functionally Related to the Phospholipse A.sub.2 Stimulatory Peptide Melittin", J. Biol. Chem. vol. 262 No. 9: 4402-4406 (1987).
Bomalaski et al., "A Phospholipase A.sub.2 -Activating Protein (PLAP) Stimulates Human Neutrophil Aggregation & Release of Lysosomal Enzymes, Superoxide, and Eicosanoids", J. of Immunol. vol. 142 No. 11: 3957-3962 (1989).
Heikkila et al., Nature vol. 328: 445-449 (1987).
Green et al., "Circulating Phospholipase A.sub.2 Activity Associated with Sepsis and Septic Shock is Indistinguishable from that Associated with Rheumatoid Arthritis", Inflammation vol. 15, Nol. 5: 355-367 (1991).
Bomalaski et al., J. Immunol. vol. 145 No. 10: 3391-3397 (1990).
Bomalaski John S.
Clark Michael A.
Shorr Robert
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