DNA encoding PHE a feedback inhibition resistant enzyme analogue

Details DNA encoding PHE a feedback inhibition resistant enzyme analogue DNA encoding PHE a feedback inhibition resistant enzyme analogue

1989-09-20

1992-06-09

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2102

Patent

active

051208377

ABSTRACT:
Disclosed are DNA sequences bonding deletion, substitution and/or addition analogs of the E. coli enzyme, chorismate mutase/prephenate dehydratase (CMPD). Preferred expression products include [des-Gln.sup.307, des-Ala.sup.308, des-Gly.sup.309, des-Ala.sup.310 ]CMPD; [Leu.sup.306 ]CMPD; [des-Thr.sup.304, Lys.sup.305, des-Gln.sup.306 ]CMPD; and [Cys.sup.309 ]CMPD display enzymatic activity of the wild type enzyme but are more resistant to inhibition in the presence of phenylalanine.

REFERENCES:
Todd et al., Journal of Bacteriology, 167 (1), 257-264 (1986).
Miura et al., Gene, 38, 271-274 (1985).
Shioda et al., Nucleic Acids Research, 14 (4), 1545-1563 (1986).
Glaser et al., The EMBO Journal, 7(12), 3997-4004 (1988).
Hudson et al., J. Mol. Biol. 180, 1023-1051 (1984).

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