DNA encoding PH-20 proteins

Details DNA encoding PH-20 proteins DNA encoding PH-20 proteins

1991-10-21

1998-02-24

Sidberry, Hazel F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 530350, 530300, 424561, 424559, 424811, C07H 1900, C07H 2100, C07H 2104, A61K 3552

Patent

active

057213488

ABSTRACT:
The disclosure relates to isolated DNA encoding all or a portion of a surface protein present in sperm of a mammal. This surface protein of sperm is essential for fertilization in the mammal. Preferably, the sperm surface protein is the PH-20 protein.

REFERENCES:
Primakoff & Myles, Gamete Interaction: Prospects for Immunocontraception pp. 89-102, Wiley-Liss, Inc. (1990).
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Lathrop et al. J. Cell Biol., 111:2939-2949 (1990).
Phelps et al., Science, 240: 1780-1782 (1988).
Primakoff et al., Nature, 335: 543-546 (1988).
Primakoff et al., Biol. Reprodu., 38:921-934 (1988).
Phelps & Myles, Dev. Biol., 123: 63-72 (1987).
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Blobel et al., J. Cell Biol. 111: 69-78 (1990).
Site-Specific Endeproterlytic Activity in Sperm Preporalus that Cleunes PH 20 into Two Disulfide-Linked Fragments.
Lathrop et al. J. Cell Biol. 109:125a Abst # 674 Nov. 5-9 1989. Cloning & Sequency of the Gene for the PH 20 protein of Guinea Sperm.
Young et al (PNAS 80:1194-1198, 1983) Efficient isolation of genes by using antibody probes.
Lathrop et al J. Cell Biol. 111:2939-2949, 1990 cDNA Cloning Reveals the Molecular Structure of a Sperm Surface Protein PH 20, Involved in Sperm-Egg Adhesion & the Wide Distribution of its Gene Among Mammals.
Primakoff et al. Biology of Reproduction 38:921-934 1988 Purification of the Guinea Pig Sperm PH 20 Antigen & Detection of a Sambrook Molecular Cloning Chapter 17 Expression of Cloned Genes in Escherichia coli.
Int'l Search Report 18 Sep. 1991 PCT Int'l.
Lin et al PNAS, Molecular Cloning of the Human & Monkey sperm surface protein PH 20 90: 10011-10015 1993.
Aitken et al, British Medical Bulletin 49: 88-99, 1993 Contraceptive Vaccine.
Naz et al Human Reproduction 5:511-518, 1990. Review Development of antisperm contraceptive vaccine for humans: Why & How?.

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